Bills vs. Broncos odds, line, spread: Monday Night Football picks, NFL predictions by model on 28-15 run

The Denver Broncos will try to stay on a roll when they visit the Buffalo Bills on Monday Night Football at Highmark Stadium. After losing its first three games of the season, including a record-breaking 50-point defeat to Miami in Week 3, Denver (3-5) has won three of its last five games, including the last two. The Broncos are looking for their first three-game winning streak since they won their first three games of the 2021 season. Buffalo (5-4) is off to its worst start to a year since the team went 2-7 to begin the 2018 season.

Kickoff is scheduled for 8:15 p.m. ET. Buffalo is a seven-point favorite in the latest Bills vs. Broncos odds while the over/under for total points scored is 47.5. Before you make any Broncos vs. Bills picks, you need to see the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2023 NFL season on an incredible 174-123 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 28-15 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has zeroed in on Bills vs. Broncos and just revealed its picks and predictions. You can visit SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Broncos vs. Bills:

  • Bills vs. Broncos spread: Buffalo -7
  • Bills vs. Broncos over/under: 47.5 points
  • Bills vs. Broncos money line: Buffalo -325, Denver +254
  • BUF: WR Stefon Diggs leads the league in receptions (70)
  • DEN: QB Russell Wilson ranks fifth in the NFL in passer rating (101.7)
  • Bills vs. Broncos: See picks here
  • Bills vs. Broncos live stream: fubo (try for free)

Why the Bills can cover

Buffalo is one of the best pass-rushing teams in the league. The Bills have 29 sacks, which ranks fifth in the NFL. Three players – Leonard Floyd (seven sacks), Ed Olver (five) and A.J. Epenesa (five) – have at least five sacks each, and no team in the league has more five-sack players.

In addition, Buffalo faces a Denver team that has struggled on the road this season. The Broncos are 1-2 away from Empower Field this year and have been outscored by 58 points in those three games. Just four teams have been outscored by more on the road this year. See which team to pick here.

Why the Broncos can cover

The Denver defense has vastly improved over the last three weeks. Over the first five games of the season, the Broncos allowed 36.2 points and 450.6 yards per game as they went 1-4. In the last three weeks, Denver has given up just 15.0 points and 331.7 yards a game. The Broncos are 2-1 over that stretch.

In addition, receiver Courtland Sutton enters the game on a roll. The 6-foot-4 Sutton has scored a receiving touchdown in his last three games. Entering Week 10, that was tied for the longest active streak in the league with A.J. Brown and Christian McCaffrey. See which team to pick here.

How to make Bills vs. Broncos picks

SportsLine’s model is leaning Over on the point total, predicting 48 total points. The model also says one side of the spread hits in almost 60% of simulations. You can see the model’s NFL picks and analysis only at SportsLine. 

So who wins Broncos vs. Bills on Monday Night Football and which side of the spread hits almost 60% of the time? Visit SportsLine now to see which side of the Broncos vs. Bills spread you should jump on, all from the advanced model that is up well over $7,000 on top-rated NFL picks, and find out.

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