Lions vs. 49ers prediction, odds, spread, line, time: 2024 NFC Championship Game picks from model on 38-21 run

The San Francisco 49ers will welcome the Detroit Lions to Levi’s Stadium on Sunday for the 2024 NFC Championship Game. The winner will take on either the Kansas City Chiefs or Baltimore Ravens in Super Bowl LVIII. It is the third all-time playoff meeting between San Francisco and Detroit, and the Lions will try to reach the Super Bowl for the first time. Detroit is also aiming to stop an 11-game road playoff losing streak, the longest in NFL history, while San Francisco is seeking an eighth Super Bowl appearance in its 19th conference championship game. 

Kickoff is at 6:30 p.m. ET in Santa Clara. The 49ers are 7.5-point favorites, while the over/under, or total number of points Vegas thinks will be scored, is 51.5 in the latest Lions vs. 49ers odds. Before you make any Lions vs. 49ers picks, you need to see the NFL predictions and betting advice from SportsLine’s advanced computer simulation model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the conference championship round of the 2024 NFL playoffs on an incredible 184-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 38-21 roll on top-rated picks since Week 7 of last season and nailed seven straight top-rated picks entering the 2024 NFL playoffs. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Lions vs. 49ers and just locked in its picks and NFL playoff predictions. You can head to SportsLine now to see the model’s picks. Now, here are several NFL odds and betting lines for Lions vs. 49ers:

  • Lions vs. 49ers spread: 49ers -7.5
  • Lions vs. 49ers over/under: 51.5 points 
  • Lions vs. 49ers money line: 49ers -348, Lions +275
  • DET: Lions are 7-2 against the spread in road games 
  • SF: 49ers are 3-6 against the spread in home games
  • Lions vs. 49ers picks: See picks at SportsLine
  • Lions vs. 49ers live stream: fubo (try for free)

Why the Lions can cover

The Lions ranked in the top five of the NFL in scoring offense (27.1 points per game) and total offense (394.8 yards per game) this season. The Lions were also in the top five in yards per play (5.9), passing yards (258.9 per game), passing touchdowns (30), and sacks allowed (31), with Jared Goff operating an elite offense from the quarterback position.

The Lions also benefit from elite options at wide receiver and tight end. Amon-Ra St. Brown has 15 receptions for 187 yards and a touchdown across two playoff games and has 10 games with 100 yards or more this season. St. Brown ranked in the top four of the NFL in receptions (119), receiving yards (1,515), and receiving touchdowns (10). At tight end, Sam LaPorta was a Pro Bowl selection as a rookie and caught nine passes against Tampa Bay in the Divisional Round. LaPorta ranked in the top five of the NFL in receptions (86) and receiving yards (889) among tight ends and had the second-most touchdown receptions (11) by a tight end in league history. See which team to pick here.

Why the 49ers can cover

The 49ers were in the top four of the NFL in passing yards (257.9 per game) and passing touchdowns (33) this season, helping to boost the team’s overall offense into the top three of the league in points per game, points per drive, scoring percentage, yards per play, total yards, and yards per drive. Quarterback Brock Purdy set an NFL record in averaging 9.6 yards per pass attempt and the Pro Bowler was in the top five of the league in passing yards (4,280), passing touchdowns (31), touchdowns rate (7.0%), passer rating (113.0), completion rate (69.4%), and QBR (72.8).

The 49ers have one of the most versatile running backs in the league in Christian McCaffrey, who led the NFL in yards from scrimmage and total touchdowns. San Francisco also has George Kittle, who led all tight ends with 1,020 receiving yards this season. From there, Detroit is shaky against the pass, ranking No. 27 in passing yards allowed (247.4 per game) and passing touchdowns allowed (28), with bottom-five marks in yards allowed per pass attempt (7.8) and red zone efficiency allowed (66.0%). The Lions are also coming off back-to-back playoff games in which they allowed more than 400 total yards and combined to yield more than seven yards per play to opposing offenses. See which team to pick here.

How to make Lions vs. 49ers picks

SportsLine’s model is leaning Under the point total, with no pass-catcher projected to generate more than 85 receiving yards. The model also says one side of the spread hits in well over 50% of simulations. You can only see the model’s pick at SportsLine.

So who wins Lions vs. 49ers in the 2024 NFC Championship Game, and which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the Lions vs. 49ers spread you need to jump on Sunday, all from the model that is up well over $7,000 for $100 players on top-rated NFL picks since its inception, and find out.  

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